D68.52
Prothrombin gene mutation
Billable FY2026 2025-10-01 → 2026-09-30
Exclusions 21 never code together
D68.5code
Excludes1
- antiphospholipid syndrome (D68.61)D68.61
- lupus anticoagulant (D68.62)D68.62
- secondary activated protein C resistance (D68.69)D68.69
- secondary antiphospholipid antibody syndrome (D68.69)D68.69
- secondary lupus anticoagulant with hypercoagulable state (D68.69)D68.69
- secondary systemic lupus erythematosus [SLE] inhibitor with hypercoagulable state (D68.69)D68.69
- systemic lupus erythematosus [SLE] inhibitor finding without diagnosis (R76.0)R76.0
- systemic lupus erythematosus [SLE] inhibitor with hemorrhagic disorder (D68.312)D68.312
- thrombotic thrombocytopenic purpura (M31.19)M31.19
D68code
D50-D89chapter
Excludes2
- autoimmune disease (systemic) NOS (M35.9)M35.9
- certain conditions originating in the perinatal period (P00-P96)P00-P96
- complications of pregnancy, childbirth and the puerperium (O00-O9A)O00-O9A
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)Q00-Q99
- endocrine, nutritional and metabolic diseases (E00-E88)E00-E88
- human immunodeficiency virus [HIV] disease (B20)B20
- injury, poisoning and certain other consequences of external causes (S00-T88)S00-T88
- neoplasms (C00-D49)C00-D49
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)R00-R94
Excludes1 — never code together. The excluded condition and this one are mutually exclusive.
Excludes2 — not included here, but the patient may have both. Code both when documented.
Instructional notes 1
D68.5code
Inclusion terms
- Primary hypercoagulable states
Index entries leading here 3
Alongside this code 2 same parent — D68.5
Additional references
AHA Coding Clinic® Licence required
Official coding advice for this code. Published by the American Hospital Association. Not included in this installation.