Reserved for future guideline expansion
D68.51
BookmarkActivated protein C resistance
Filed alongside this entry 3
under Mutation (s)
Index entries, exactly as the book files them. This says they are listed together — not that any of them is documented in your chart.
Billable FY2027 2026-10-01 → 2027-09-30
How to use this page
Everything the published sources say about one code, on one page.
- Read the Excludes1 block first — it is the one that stops you coding this at all alongside another code.
- Excludes2, Code first, Use additional and Includes follow. A note inherited from a parent category is labelled with the category it came from, so you can see why it applies.
- Official Guidelines sit below. "Guidelines naming this code" cite the code or a range containing it; "Chapter guidance" is the general guidance for its chapter and is the weaker signal.
- Guideline text is quoted verbatim with its section number and page, so you can check it against the published document.
- Risk-model chips show which published CMS models map this code.
What this page does not do
- Guidance is quoted, never paraphrased — a paraphrase of a coding rule is a different rule.
- Medication candidates, where shown, are matched by condition *name* and are offered as candidates for you to judge. They are not "the drugs for this code".
Exclusions21never code together
D68code
D68.5code
Excludes1
- antiphospholipid syndrome (D68.61)D68.61
- lupus anticoagulant (D68.62)D68.62
- secondary activated protein C resistance (D68.69)D68.69
- secondary antiphospholipid antibody syndrome (D68.69)D68.69
- secondary lupus anticoagulant with hypercoagulable state (D68.69)D68.69
- secondary systemic lupus erythematosus [SLE] inhibitor with hypercoagulable state (D68.69)D68.69
- systemic lupus erythematosus [SLE] inhibitor finding without diagnosis (R76.0)R76.0
- systemic lupus erythematosus [SLE] inhibitor with hemorrhagic disorder (D68.312)D68.312
- thrombotic thrombocytopenic purpura (M31.19)M31.19
D50-D89chapter
Excludes2
- autoimmune disease (systemic) NOS (M35.9)M35.9
- certain conditions originating in the perinatal period (P00-P96)P00-P96
- complications of pregnancy, childbirth and the puerperium (O00-O9A)O00-O9A
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)Q00-Q99
- endocrine, nutritional and metabolic diseases (E00-E88)E00-E88
- human immunodeficiency virus [HIV] disease (B20)B20
- injury, poisoning and certain other consequences of external causes (S00-T88)S00-T88
- neoplasms (C00-D49)C00-D49
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)R00-R94
Excludes1 — never code together. The excluded condition and this one are mutually exclusive.
Excludes2 — not included here, but the patient may have both. Code both when documented.
Instructional notes2
Official Guidelines1names this code
ICD-10-CM Official Guidelines for Coding and Reporting, quoted in full. Published by CMS and NCHS; in the public domain.
Index entries leading here4
Alongside this code2same parent — D68.5
Additional references
AHA Coding Clinic® Licence required
Official coding advice for this code. Published by the American Hospital Association. Not included in this installation.