I27.21

Secondary pulmonary arterial hypertension

Billable FY2026 2025-10-01 → 2026-09-30

Exclusions 11 never code together

I27.2code

Excludes1

Eisenmenger's syndrome (I27.83)I27.83

I00-I99chapter

Excludes2

certain conditions originating in the perinatal period (P04-P96)P04-P96
certain infectious and parasitic diseases (A00-B99)A00-B99
complications of pregnancy, childbirth and the puerperium (O00-O9A)O00-O9A
congenital malformations, deformations, and chromosomal abnormalities (Q00-Q99)Q00-Q99
endocrine, nutritional and metabolic diseases (E00-E88)E00-E88
injury, poisoning and certain other consequences of external causes (S00-T88)S00-T88
neoplasms (C00-D49)C00-D49
symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)R00-R94
systemic connective tissue disorders (M30-M36)M30-M36
transient cerebral ischemic attacks and related syndromes (G45.-)G45.-

Excludes1 — never code together. The excluded condition and this one are mutually exclusive.

Excludes2 — not included here, but the patient may have both. Code both when documented.

Instructional notes 13

I27.21code

Inclusion terms

(Associated) (drug-induced) (toxin-induced) pulmonary arterial hypertension NOS
(Associated) (drug-induced) (toxin-induced) (secondary) group 1 pulmonary hypertension

Code also

associated conditions if applicable, or adverse effects of drugs or toxins, such as:
adverse effect of appetite depressants (T50.5X5)T50.5X5
congenital heart disease (Q20-Q28)Q20-Q28
human immunodeficiency virus [HIV] disease (B20)B20
polymyositis (M33.2-)M33.2-
portal hypertension (K76.6)K76.6
rheumatoid arthritis (M05.-)M05.-
schistosomiasis (B65.-)B65.-
Sjögren syndrome (M35.0-)M35.0-
systemic sclerosis (M34.-)M34.-

I27.2code

Code also

associated underlying condition

Index entries leading here 1

Hypertension, hypertensive (accelerated) (benign) (essential) (idiopathic) (malignant) (systemic) I10
- pulmonary I27.20
  - secondary
    - arterial I27.21
  - arterial (associated) (drug-induced) (toxin-induced) I27.21
  - group 1 (associated) (drug-induced) (toxin-induced) I27.21

Alongside this code 5 same parent — I27.2

I27.20 Pulmonary hypertension, unspecified I27.22 Pulmonary hypertension due to left heart disease I27.23 Pulmonary hypertension due to lung diseases and hypoxia I27.24 Chronic thromboembolic pulmonary hypertension I27.29 Other secondary pulmonary hypertension

Medications 2

2 Pulmonary Arterial Hypertension drugs 34 Hypertension, Pulmonary drugs

MED-RT files conditions by MeSH, which carves the world differently from ICD-10. These are name matches on this code's description, offered as candidates — not as an assertion that they are this code.

Additional references

AHA Coding Clinic® Licence required

Official coding advice for this code. Published by the American Hospital Association. Not included in this installation.

Risk adjustment

CMS22HCC85 CMS28HCC226 ESRD21HCC85 ESRD24HCC85 RX08HCC183

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This code

Billable: yes
Code set: FY2026
Parent: I27.2
Block: I26-I28
Siblings: 5

Present FY2024–FY2027.