E75.25

Metachromatic leukodystrophy

Billable FY2026 2025-10-01 → 2026-09-30

Exclusions 10 never code together

E75.2code

Excludes1

adrenoleukodystrophy [Addison-Schilder] (E71.528)E71.528

E75code

Excludes1

mucolipidosis, types I-III (E77.0-E77.1)E77.0-E77.1
Refsum's disease (G60.1)G60.1

E70-E88block

Excludes1

androgen insensitivity syndrome (E34.5-)E34.5-
congenital adrenal hyperplasia (E25.0)E25.0
hemolytic anemias attributable to enzyme disorders (D55.-)D55.-
Marfan syndrome (Q87.4-)Q87.4-
5-alpha-reductase deficiency (E29.1)E29.1

Excludes2

Ehlers-Danlos syndromes (Q79.6-)Q79.6-

E00-E89chapter

Excludes1

transitory endocrine and metabolic disorders specific to newborn (P70-P74)P70-P74

Excludes1 — never code together. The excluded condition and this one are mutually exclusive.

Excludes2 — not included here, but the patient may have both. Code both when documented.

Instructional notes 1

E00-E89chapter

Notes

All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.E05.8 E07.0 E16-E31 E34.-

Index entries leading here 4

Greenfield's disease
- meaning
  - metachromatic leukodystrophy E75.25
Leukodystrophy G31.80
- metachromatic E75.25
Leukoencephalopathy G93.49
- metachromatic E75.25
Scholz (-Bielchowsky-Henneberg) disease or syndrome E75.25

Alongside this code 8 same parent — E75.2

E75.21 Fabry (-Anderson) disease E75.22 Gaucher disease E75.23 Krabbe disease E75.24 Niemann-Pick disease category E75.26 Sulfatase deficiency E75.27 Pelizaeus-Merzbacher disease E75.28 Canavan disease E75.29 Other sphingolipidosis

Medications 1

1 Leukodystrophy, Metachromatic drugs

MED-RT files conditions by MeSH, which carves the world differently from ICD-10. These are name matches on this code's description, offered as candidates — not as an assertion that they are this code.

Additional references

AHA Coding Clinic® Licence required

Official coding advice for this code. Published by the American Hospital Association. Not included in this installation.

Risk adjustment

ESRD21HCC52 ESRD24HCC52 RX08HCC41

Presence is a property of the code. Untick a model to hide it everywhere.

This code

Billable: yes
Code set: FY2026
Parent: E75.2
Block: E70-E88
Siblings: 8

Present FY2024–FY2027.