E34.321
Primary insulin-like growth factor-1 (IGF-1) deficiency
Billable FY2026 2025-10-01 → 2026-09-30
Exclusions 15 never code together
E34.3code
Excludes1
- achondroplastic short stature (Q77.4)Q77.4
- hypochondroplastic short stature (Q77.4)Q77.4
- nutritional short stature (E45)E45
- pituitary short stature (E23.0)E23.0
- progeria (E34.8)E34.8
- renal short stature (N25.0)N25.0
- Russell-Silver syndrome (Q87.19)Q87.19
- short-limbed stature with immunodeficiency (D82.2)D82.2
- short stature (child) (R62.52)R62.52
- short stature in specific dysmorphic syndromes - code to syndrome - see Alphabetical Index
- short stature NOS (R62.52)R62.52
E00-E89chapter
Excludes1
- transitory endocrine and metabolic disorders specific to newborn (P70-P74)P70-P74
Excludes1 — never code together. The excluded condition and this one are mutually exclusive.
Instructional notes 8
E34.321code
Inclusion terms
- Acid-labile subunit gene (IGFALS) defect
- Growth hormone gene 1 (GH1) defect with growth hormone neutralizing antibodies
- Growth hormone insensitivity syndrome (GHIS)
- Insulin-like growth factor 1 gene (IGF1) defect
- Laron type short stature
- Severe primary insulin-like growth factor-1 deficiency (SPIGFD)
- Signal transducer and activator of transcription 5B gene (STAT5b) defect
E00-E89chapter
Notes
- All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.E05.8E07.0E16-E31E34.-
Index entries leading here 2
- Short, shortening, shortness
- stature (child) (hereditary) (idiopathic) NEC R62.52
- due to
- genetic causes E34.329
- acid-labile subunit gene (IGFALS) defect E34.321
- growth hormone gene 1 (GH1) defect with growth hormone neutralizing antibodies E34.321
- signal transducer and activator of transcription 5B gene (STAT5b) defect E34.321
- insulin-like growth factor 1 gene (IGF1) defect E34.321
- primary insulin-like growth factor-1 (IGF-1) deficiency E34.321
- severe primary insulin-like growth factor-1 deficiency (SPIGFD) E34.321
- growth hormone insensitivity syndrome (GHIS) E34.321
- genetic causes E34.329
- Laron-type E34.321
- due to
- stature (child) (hereditary) (idiopathic) NEC R62.52
- Dwarfism E34.328
- Laron-type E34.321
Alongside this code 3 same parent — E34.32
Additional references
AHA Coding Clinic® Licence required
Official coding advice for this code. Published by the American Hospital Association. Not included in this installation.