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D59.31

Infection-associated hemolytic-uremic syndrome

Billable FY2026 2025-10-01 → 2026-09-30
Exclusions 9 never code together
D50-D89chapter
Excludes2
  • autoimmune disease (systemic) NOS (M35.9)M35.9
  • certain conditions originating in the perinatal period (P00-P96)P00-P96
  • complications of pregnancy, childbirth and the puerperium (O00-O9A)O00-O9A
  • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)Q00-Q99
  • endocrine, nutritional and metabolic diseases (E00-E88)E00-E88
  • human immunodeficiency virus [HIV] disease (B20)B20
  • injury, poisoning and certain other consequences of external causes (S00-T88)S00-T88
  • neoplasms (C00-D49)C00-D49
  • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)R00-R94

Excludes2 — not included here, but the patient may have both. Code both when documented.

Instructional notes 13
D59.31code
Inclusion terms
  • Shiga toxin-producing E. coli [STEC] related hemolytic uremic syndrome
  • Typical hemolytic uremic syndrome
Use additional code
  • code to identify associated infection, such as :
  • E. coli infection (B96.2-)B96.2-
  • Human immunodeficiency virus [HIV] disease (B20)B20
  • Pneumococcal meningitis (G00.1)G00.1
  • Pneumococcal pneumonia (J13)J13
  • Sepsis due to Streptococcus pneumoniae (A40.3)A40.3
  • Shigella dysenteriae (A03.9)A03.9
  • Streptococcus pneumoniae as the cause of diseases classified elsewhere (B95.3)B95.3
D59.3code
Code also
  • , if applicable, any associated:
  • acute kidney failure (N17.-)N17.-
  • chronic kidney disease (N18.-)N18.-
Official Guidelines 3 names this code

ICD-10-CM Official Guidelines for Coding and Reporting, quoted in full. Published by CMS and NCHS; in the public domain.

I.C.1.a.2.b Patient admitted for HIV-related condition names this code p.20

If a patient is admitted for an HIV-related condition, the principal diagnosis should be B20, Human immunodeficiency virus [HIV] disease followed by additional diagnosis codes for all reported HIV-related conditions. An exception to this guideline is if the reason for admission is hemolytic-uremic syndrome associated with HIV disease. Assign code D59.31, Infection-associated hemolytic-uremic syndrome, followed by code B20, Human immunodeficiency virus [HIV] disease.

I.C.1.d.9 Hemolytic-uremic syndrome associated with sepsis names this code p.26

If the reason for admission is hemolytic-uremic syndrome that is associated with sepsis, assign code D59.31, Infection-associated hemolytic-uremic syndrome, as the principal diagnosis. Codes for the underlying systemic infection and any other conditions (such as severe sepsis) should be assigned as secondary diagnoses.

I.C.3 Chapter 3: Disease of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89) names this code p.39

Reserved for future guideline expansion

Index entries leading here 1
  • Syndrome — see also Disease
Alongside this code 3 same parent — D59.3
Additional references
AHA Coding Clinic® Licence required

Official coding advice for this code. Published by the American Hospital Association. Not included in this installation.

Risk adjustment

CMS22HCC46 CMS28HCC109 ESRD21HCC46 ESRD24HCC46 RX08HCC96

Presence is a property of the code. Untick a model to hide it everywhere.

This code

Billable
yes
Code set
FY2026
Parent
D59.3
Block
D55-D59
Siblings
3

Present FY2024–FY2027.