D56.4

Hereditary persistence of fetal hemoglobin [HPFH]

Billable FY2026 2025-10-01 → 2026-09-30

Exclusions 10 never code together

D56code

Excludes1

Excludes2

autoimmune disease (systemic) NOS (M35.9)M35.9
certain conditions originating in the perinatal period (P00-P96)P00-P96
complications of pregnancy, childbirth and the puerperium (O00-O9A)O00-O9A
congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)Q00-Q99
endocrine, nutritional and metabolic diseases (E00-E88)E00-E88
human immunodeficiency virus [HIV] disease (B20)B20
injury, poisoning and certain other consequences of external causes (S00-T88)S00-T88
neoplasms (C00-D49)C00-D49
symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)R00-R94

Excludes1 — never code together. The excluded condition and this one are mutually exclusive.

Excludes2 — not included here, but the patient may have both. Code both when documented.

Instructional notes

No further instructional notes apply.

Official Guidelines 1 names this code

ICD-10-CM Official Guidelines for Coding and Reporting, quoted in full. Published by CMS and NCHS; in the public domain.

I.C.3 Chapter 3: Disease of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89) names this code p.39

Reserved for future guideline expansion

Index entries leading here 2

Persistence, persistent (congenital)
- fetal
  - hemoglobin, hereditary (HPFH) D56.4
- hemoglobin, fetal (hereditary) (HPFH) D56.4
Hemoglobin — see also condition
- fetal, hereditary persistence (HPFH) D56.4

Alongside this code 7 same parent — D56

Additional references

AHA Coding Clinic® Licence required

Official coding advice for this code. Published by the American Hospital Association. Not included in this installation.

CMS22HCC48 ESRD21HCC48 ESRD24HCC48

Presence is a property of the code. Untick a model to hide it everywhere.

Present FY2024–FY2027.