D53.0

Protein deficiency anemia

Billable FY2026 2025-10-01 → 2026-09-30

Exclusions 10 never code together

D53.0code

Excludes1

Lesch-Nyhan syndrome (E79.1)E79.1 E79.1

D50-D89chapter

Excludes2

autoimmune disease (systemic) NOS (M35.9)M35.9
certain conditions originating in the perinatal period (P00-P96)P00-P96
complications of pregnancy, childbirth and the puerperium (O00-O9A)O00-O9A
congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)Q00-Q99
endocrine, nutritional and metabolic diseases (E00-E88)E00-E88
human immunodeficiency virus [HIV] disease (B20)B20
injury, poisoning and certain other consequences of external causes (S00-T88)S00-T88
neoplasms (C00-D49)C00-D49
symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)R00-R94

Excludes1 — never code together. The excluded condition and this one are mutually exclusive.

Excludes2 — not included here, but the patient may have both. Code both when documented.

Instructional notes 3

D53code

Includes

megaloblastic anemia unresponsive to vitamin B12 or folate therapyB12

D53.0code

Inclusion terms

Amino-acid deficiency anemia
Orotaciduric anemia

Index entries leading here 5

Aciduria
- orotic (congenital) (hereditary) (pyrimidine deficiency) E79.89
  - anemia D53.0
Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) D64.9
- due to (in) (with)
  - deficiency
    - amino-acid D53.0
    - protein D53.0
- deficiency D53.9
  - amino-acid D53.0
  - protein D53.0
- amino-acid-deficiency D53.0
- megaloblastic D53.1
  - orotic aciduria D53.0
- orotaciduric (congenital) (hereditary) D53.0
- protein-deficiency D53.0
Amino-acid disorder E72.9
- anemia D53.0
Orotaciduria, oroticaciduria (congenital) (hereditary) (pyrimidine deficiency) E79.89
- anemia D53.0
Deficiency, deficient
- protein E46
  - anemia D53.0

Alongside this code 4 same parent — D53

D53.1 Other megaloblastic anemias, not elsewhere classified D53.2 Scorbutic anemia D53.8 Other specified nutritional anemias D53.9 Nutritional anemia, unspecified

Medications 4

6 Protein Deficiency drugs 41 Anemia, Iron-Deficiency drugs 1 Protein S Deficiency drugs 1 Protein C Deficiency drugs

MED-RT files conditions by MeSH, which carves the world differently from ICD-10. These are name matches on this code's description, offered as candidates — not as an assertion that they are this code.

Additional references

AHA Coding Clinic® Licence required

Official coding advice for this code. Published by the American Hospital Association. Not included in this installation.

Risk adjustment

Maps to no condition category in any loaded model.

Presence is a property of the code. Untick a model to hide it everywhere.

This code

Billable: yes
Code set: FY2026
Parent: D53
Block: D50-D53
Siblings: 4

Present FY2024–FY2027.