G12.21

Amyotrophic lateral sclerosis

Billable FY2026 2025-10-01 → 2026-09-30 valid age >= 15

Exclusions 8 never code together

G00-G99chapter

Excludes2

certain conditions originating in the perinatal period (P04-P96)P04-P96
certain infectious and parasitic diseases (A00-B99)A00-B99
complications of pregnancy, childbirth and the puerperium (O00-O9A)O00-O9A
congenital malformations, deformations, and chromosomal abnormalities (Q00-Q99)Q00-Q99
endocrine, nutritional and metabolic diseases (E00-E88)E00-E88
injury, poisoning and certain other consequences of external causes (S00-T88)S00-T88
neoplasms (C00-D49)C00-D49
symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)R00-R94

Excludes2 — not included here, but the patient may have both. Code both when documented.

Instructional notes

No further instructional notes apply.

Index entries leading here 6

Amyotrophia, amyotrophy, amyotrophic G71.8
- lateral sclerosis G12.21
Paralysis, paralytic (complete) (incomplete) G83.9
- amyotrophic G12.21
- muscle, muscular NEC G72.89
  - progressive G12.21
- spinal (cord) G83.9
  - progressive G12.21
Sclerosis, sclerotic
- amyotrophic (lateral) G12.21
- spinal (cord) (progressive) G95.89
  - lateral (amyotrophic) G12.21
- lateral (amyotrophic) (descending) (spinal) G12.21
Disease, diseased — see also Syndrome
- motor neuron (bulbar) (mixed type) (spinal) G12.20
  - amyotrophic lateral sclerosis G12.21
Atrophy, atrophic (of)
- muscle, muscular (diffuse) (general) (idiopathic) (primary) M62.50
  - spinal G12.9
    - Aran-Duchenne G12.21
  - progressive (bulbar) G12.21
  - Duchenne-Aran G12.21
- Duchenne-Aran G12.21
Duchenne-Aran muscular atrophy G12.21

Alongside this code 6 same parent — G12.2

G12.20 Motor neuron disease, unspecified G12.22 Progressive bulbar palsy G12.23 Primary lateral sclerosis G12.24 Familial motor neuron disease G12.25 Progressive spinal muscle atrophy G12.29 Other motor neuron disease

Medications 1

5 Amyotrophic Lateral Sclerosis drugs

MED-RT files conditions by MeSH, which carves the world differently from ICD-10. These are name matches on this code's description, offered as candidates — not as an assertion that they are this code.

Additional references

AHA Coding Clinic® Licence required

Official coding advice for this code. Published by the American Hospital Association. Not included in this installation.

Risk adjustment

CMS22HCC73 CMS28HCC190 ESRD21HCC73 ESRD24HCC73 RX08HCC154

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This code

Billable: yes
Code set: FY2026
Parent: G12.2
Block: G10-G14
Siblings: 6

Present FY2024–FY2027.