E85.4

Organ-limited amyloidosis

Billable FY2026 2025-10-01 → 2026-09-30

Exclusions 8 never code together

E85code

Excludes2

Alzheimer's disease (G30.0-)G30.0-

E70-E88block

Excludes1

androgen insensitivity syndrome (E34.5-)E34.5-
congenital adrenal hyperplasia (E25.0)E25.0
hemolytic anemias attributable to enzyme disorders (D55.-)D55.-
Marfan syndrome (Q87.4-)Q87.4-
5-alpha-reductase deficiency (E29.1)E29.1

Excludes2

Ehlers-Danlos syndromes (Q79.6-)Q79.6-

E00-E89chapter

Excludes1

transitory endocrine and metabolic disorders specific to newborn (P70-P74)P70-P74

Excludes1 — never code together. The excluded condition and this one are mutually exclusive.

Excludes2 — not included here, but the patient may have both. Code both when documented.

Instructional notes 3

E85.4code

Inclusion terms

Localized amyloidosis
Transthyretin-related (ATTR) familial amyloid cardiomyopathy

E00-E89chapter

Notes

All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.E05.8 E07.0 E16-E31 E34.-

Index entries leading here 16

Degeneration, degenerative
- cutis L98.8
  - amyloid E85.4
- liver (diffuse) NEC K76.89
  - amyloid E85.4
- kidney N28.89
  - amyloid E85.4
- spleen D73.0
  - amyloid E85.4
- spinal (cord) G31.89
  - amyloid E85.4
- nervous system G31.9
  - amyloid E85.4
- heart — see also Degeneration, myocardial
  - amyloid E85.4
- skin L98.8
  - amyloid E85.4
- artery, arterial (atheromatous) (calcareous) — see also Arteriosclerosis
  - cerebral, amyloid E85.4
- intestine, amyloid E85.4
Nephritis, nephritic (albuminuric) (azotemic) (congenital) (disseminated) (epithelial) (familial) (focal) (granulomatous) (hemorrhagic) (infantile) (nonsuppurative, excretory) (uremic) N05.9
- amyloid E85.4
Disease, diseased — see also Syndrome
- spleen D73.9
  - amyloid E85.4
- heart (organic) I51.9
  - amyloid E85.4
- gastrointestinal (tract) K92.9
  - amyloid E85.4
- lung J98.4
  - in
    - amyloidosis E85.4
Angiopathia, angiopathy I99.9
- cerebral I67.9
  - amyloid E85.4
Cardiomyopathy (familial) (idiopathic) I42.9
- amyloid E85.4
  - transthyretin-related (ATTR) familial E85.4
- transthyretin-related (ATTR) familial amyloid E85.4
Neuritis (rheumatoid) M79.2
- amyloid, any site E85.4
Amyloid heart (disease) E85.4
Neuropathy, neuropathic G62.9
- peripheral (nerve) G62.9
  - autonomic G90.9
    - in (due to)
      - amyloidosis E85.4
Arthritis, arthritic (acute) (chronic) (nonpyogenic) (subacute) M19.90
- in (due to)
  - amyloidosis E85.4
Arthropathy M12.9
- in (due to)
  - amyloidosis E85.4
Disorder (of) — see also Disease
- glomerular (in) N05.9
  - amyloidosis E85.4
Glaucoma H40.9
- in (due to)
  - amyloidosis E85.4
Glomerulonephritis N05.9
- in (due to)
  - amyloidosis E85.4
Lichen L28.0
- amyloidosis E85.4
Nephrosis, nephrotic (Epstein's) (syndrome) (congenital) N04.9
- in
  - amyloidosis E85.4
Amyloidosis (generalized) (primary) E85.9
- organ limited E85.4
- with lung involvement E85.4
- localized E85.4
- heart E85.4
- liver E85.4
- subglottic E85.4
- skin (lichen) (macular) E85.4
- pulmonary E85.4

Alongside this code 6 same parent — E85

E85.0 Non-neuropathic heredofamilial amyloidosis E85.1 Neuropathic heredofamilial amyloidosis E85.2 Heredofamilial amyloidosis, unspecified E85.3 Secondary systemic amyloidosis E85.8 Other amyloidosis category E85.9 Amyloidosis, unspecified

Additional references

AHA Coding Clinic® Licence required

Official coding advice for this code. Published by the American Hospital Association. Not included in this installation.

Risk adjustment

CMS22HCC23 CMS28HCC50 ESRD21HCC23 ESRD24HCC23

Presence is a property of the code. Untick a model to hide it everywhere.

This code

Billable: yes
Code set: FY2026
Parent: E85
Block: E70-E88
Siblings: 6

Present FY2024–FY2027.