E08.21

Diabetes mellitus due to underlying condition with diabetic nephropathy

Billable FY2026 2025-10-01 → 2026-09-30

Exclusions 9 never code together

E08code

Excludes1

drug or chemical induced diabetes mellitus (E09.-)E09.-
gestational diabetes (O24.4-)O24.4-
neonatal diabetes mellitus (P70.2)P70.2
postpancreatectomy diabetes mellitus (E13.-)E13.-
postprocedural diabetes mellitus (E13.-)E13.-
secondary diabetes mellitus NEC (E13.-)E13.-
type 1 diabetes mellitus (E10.-)E10.-
type 2 diabetes mellitus (E11.-)E11.-

E00-E89chapter

Excludes1

transitory endocrine and metabolic disorders specific to newborn (P70-P74)P70-P74

Excludes1 — never code together. The excluded condition and this one are mutually exclusive.

Instructional notes 16

E08code

Code first

the underlying condition, such as:
congenital rubella (P35.0)P35.0
Cushing's syndrome (E24.-)E24.-
cystic fibrosis (E84.-)E84.-
malignant neoplasm (C00-C96)C00-C96
malnutrition (E40-E46)E40-E46
pancreatitis and other diseases of the pancreas (K85-K86.-)K85-K86

Use additional code

code to identify control using:
injectable non-insulin antidiabetic drugs (Z79.85)Z79.85
insulin (Z79.4)Z79.4
oral antidiabetic drugs (Z79.84)Z79.84
oral hypoglycemic drugs (Z79.84)Z79.84

E08.21code

Inclusion terms

Diabetes mellitus due to underlying condition with intercapillary glomerulosclerosis
Diabetes mellitus due to underlying condition with intracapillary glomerulonephrosis
Diabetes mellitus due to underlying condition with Kimmelstiel-Wilson disease

E00-E89chapter

Notes

All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.E05.8 E07.0 E16-E31 E34.-

Index entries leading here 5

Diabetes, diabetic (mellitus) (sugar) E11.9
- due to underlying condition E08.9
  - with
    - glomerulonephrosis, intracapillary E08.21
    - glomerulosclerosis, intercapillary E08.21
    - Kimmelstiel-Wilson disease E08.21
    - nephropathy E08.21
Nephrosis, nephrotic (Epstein's) (syndrome) (congenital) N04.9
- in
  - diabetes mellitus — see E08-E13 with .21
- diabetic — see E08-E13 with .21
Nephritis, nephritic (albuminuric) (azotemic) (congenital) (disseminated) (epithelial) (familial) (focal) (granulomatous) (hemorrhagic) (infantile) (nonsuppurative, excretory) (uremic) N05.9
- due to
  - diabetes mellitus — see E08-E13 with .21
Nephropathy N28.9
- diabetic — see E08-E13 with .21
Disease, diseased — see also Syndrome
- Kimmelstiel (-Wilson) (intercapillary polycystic (congenital) glomerulosclerosis) — see E08-E13 with .21

Alongside this code 2 same parent — E08.2

E08.22 Diabetes due to undrl cond w diabetic chronic kidney disease E08.29 Diabetes due to undrl condition w oth diabetic kidney comp

Medications 3

232 Diabetes Mellitus drugs 81 Diabetes Mellitus, Type 2 drugs 49 Diabetes Mellitus, Type 1 drugs

MED-RT files conditions by MeSH, which carves the world differently from ICD-10. These are name matches on this code's description, offered as candidates — not as an assertion that they are this code.

Additional references

AHA Coding Clinic® Licence required

Official coding advice for this code. Published by the American Hospital Association. Not included in this installation.

Risk adjustment

CMS22HCC18 CMS28HCC37 ESRD21HCC141 · HCC18 ESRD24HCC18 RX08HCC30

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This code

Billable: yes
Code set: FY2026
Parent: E08.2
Block: E08-E13
Siblings: 2

Present FY2024–FY2027.