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D89.3

Immune reconstitution syndrome

Billable FY2026 2025-10-01 → 2026-09-30
Exclusions 15 never code together
D89code
Excludes1
  • hyperglobulinemia NOS (R77.1)R77.1
  • monoclonal gammopathy (of undetermined significance) (D47.2)D47.2
Excludes2
  • transplant failure and rejection (T86.-)T86.-
D80-D89block
Excludes1
  • autoimmune disease (systemic) NOS (M35.9)M35.9
  • functional disorders of polymorphonuclear neutrophils (D71-)D71-
  • human immunodeficiency virus [HIV] disease (B20)B20
D50-D89chapter
Excludes2
  • autoimmune disease (systemic) NOS (M35.9)M35.9
  • certain conditions originating in the perinatal period (P00-P96)P00-P96
  • complications of pregnancy, childbirth and the puerperium (O00-O9A)O00-O9A
  • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)Q00-Q99
  • endocrine, nutritional and metabolic diseases (E00-E88)E00-E88
  • human immunodeficiency virus [HIV] disease (B20)B20
  • injury, poisoning and certain other consequences of external causes (S00-T88)S00-T88
  • neoplasms (C00-D49)C00-D49
  • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)R00-R94

Excludes1 — never code together. The excluded condition and this one are mutually exclusive.

Excludes2 — not included here, but the patient may have both. Code both when documented.

Instructional notes 5
D89.3code
Inclusion terms
  • Immune reconstitution inflammatory syndrome [IRIS]
Use additional code
  • code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)T36-T50T36-T50
D80-D89block
Includes
  • defects in the complement system
  • immunodeficiency disorders, except human immunodeficiency virus [HIV] disease
  • sarcoidosis
Index entries leading here 2
  • Syndrome — see also Disease
    • immune reconstitution D89.3
    • immune reconstitution inflammatory [IRIS] D89.3
  • Immune reconstitution (inflammatory) syndrome [IRIS] D89.3
Alongside this code 6 same parent — D89
Medications 1

MED-RT files conditions by MeSH, which carves the world differently from ICD-10. These are name matches on this code's description, offered as candidates — not as an assertion that they are this code.

Additional references
AHA Coding Clinic® Licence required

Official coding advice for this code. Published by the American Hospital Association. Not included in this installation.

Risk adjustment

CMS22HCC47 ESRD21HCC47 ESRD24HCC47 RX08HCC99

Presence is a property of the code. Untick a model to hide it everywhere.

This code

Billable
yes
Code set
FY2026
Parent
D89
Block
D80-D89
Siblings
6

Present FY2024–FY2027.