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D80.1

Nonfamilial hypogammaglobulinemia

Billable FY2026 2025-10-01 → 2026-09-30
Exclusions 12 never code together
D80-D89block
Excludes1
  • autoimmune disease (systemic) NOS (M35.9)M35.9
  • functional disorders of polymorphonuclear neutrophils (D71-)D71-
  • human immunodeficiency virus [HIV] disease (B20)B20
D50-D89chapter
Excludes2
  • autoimmune disease (systemic) NOS (M35.9)M35.9
  • certain conditions originating in the perinatal period (P00-P96)P00-P96
  • complications of pregnancy, childbirth and the puerperium (O00-O9A)O00-O9A
  • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)Q00-Q99
  • endocrine, nutritional and metabolic diseases (E00-E88)E00-E88
  • human immunodeficiency virus [HIV] disease (B20)B20
  • injury, poisoning and certain other consequences of external causes (S00-T88)S00-T88
  • neoplasms (C00-D49)C00-D49
  • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)R00-R94

Excludes1 — never code together. The excluded condition and this one are mutually exclusive.

Excludes2 — not included here, but the patient may have both. Code both when documented.

Instructional notes 6
D80.1code
Inclusion terms
  • Agammaglobulinemia with immunoglobulin-bearing B-lymphocytes
  • Common variable agammaglobulinemia [CVAgamma]
  • Hypogammaglobulinemia NOS
D80-D89block
Includes
  • defects in the complement system
  • immunodeficiency disorders, except human immunodeficiency virus [HIV] disease
  • sarcoidosis
Index entries leading here 7
  • Absence (of) (organ or part) (complete or partial)
    • gamma globulin in blood D80.1
  • Agammaglobulinemia (acquired (secondary)) (nonfamilial) D80.1
    • with
      • immunoglobulin-bearing B-lymphocytes D80.1
    • common variable (CVAgamma) D80.1
  • Syndrome — see also Disease
    • antibody deficiency D80.9
      • agammaglobulinemic D80.1
      • hypogammaglobulinemic D80.1
  • Arthritis, arthritic (acute) (chronic) (nonpyogenic) (subacute) M19.90
    • in (due to)
      • hypogammaglobulinemia D80.1
  • Disease, diseased — see also Syndrome
    • connective tissue, systemic (diffuse) M35.9
      • in (due to)
        • hypogammaglobulinemia D80.1
  • Deficiency, deficient
    • gammaglobulin in blood D80.1
  • Hypogammaglobulinemia D80.1
Alongside this code 9 same parent — D80
Additional references
AHA Coding Clinic® Licence required

Official coding advice for this code. Published by the American Hospital Association. Not included in this installation.

Risk adjustment

CMS22HCC47 ESRD21HCC47 ESRD24HCC47 RX08HCC99

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This code

Billable
yes
Code set
FY2026
Parent
D80
Block
D80-D89
Siblings
9

Present FY2024–FY2027.