D75.81

Myelofibrosis

Billable FY2026 2025-10-01 → 2026-09-30

Exclusions 22 never code together

D75.81code

Excludes1

acute myelofibrosis (C94.4-)C94.4-
idiopathic myelofibrosis (D47.1)D47.1
leukoerythroblastic anemia (D61.82)D61.82
myelofibrosis with myeloid metaplasia (D47.4)D47.4
myelophthisic anemia (D61.82)D61.82
myelophthisis (D61.82)D61.82
primary myelofibrosis (D47.1)D47.1

D75code

Excludes2

acute lymphadenitis (L04.-)L04.-
chronic lymphadenitis (I88.1)I88.1
enlarged lymph nodes (R59.-)R59.-
hypergammaglobulinemia NOS (D89.2)D89.2
lymphadenitis NOS (I88.9)I88.9
mesenteric lymphadenitis (acute) (chronic) (I88.0)I88.0

D50-D89chapter

Excludes2

autoimmune disease (systemic) NOS (M35.9)M35.9
certain conditions originating in the perinatal period (P00-P96)P00-P96
complications of pregnancy, childbirth and the puerperium (O00-O9A)O00-O9A
congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)Q00-Q99
endocrine, nutritional and metabolic diseases (E00-E88)E00-E88
human immunodeficiency virus [HIV] disease (B20)B20
injury, poisoning and certain other consequences of external causes (S00-T88)S00-T88
neoplasms (C00-D49)C00-D49
symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)R00-R94

Excludes1 — never code together. The excluded condition and this one are mutually exclusive.

Excludes2 — not included here, but the patient may have both. Code both when documented.

Instructional notes 6

D75.81code

Inclusion terms

Myelofibrosis NOS
Secondary myelofibrosis NOS

Code first

the underlying disorder, such as:
malignant neoplasm of breast (C50.-)C50.-

Use additional code

code, if applicable, for associated therapy-related myelodysplastic syndrome (D46.-)D46.-
code for adverse effect, if applicable, to identify drug (T45.1X5)T45.1X5

Index entries leading here 3

Anemia (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound) D64.9
- myelofibrosis D75.81
Osteosclerosis Q78.2
- myelofibrosis D75.81
Myelofibrosis D75.81
- secondary D75.81

Alongside this code 4 same parent — D75.8

D75.82 Heparin induced thrombocytopenia (HIT) category D75.83 Thrombocytosis category D75.84 Other platelet-activating anti-PF4 disorders D75.89 Other specified diseases of blood and blood-forming organs

Medications 1

9 Primary Myelofibrosis drugs

MED-RT files conditions by MeSH, which carves the world differently from ICD-10. These are name matches on this code's description, offered as candidates — not as an assertion that they are this code.

Additional references

AHA Coding Clinic® Licence required

Official coding advice for this code. Published by the American Hospital Association. Not included in this installation.

Risk adjustment

CMS22HCC46 CMS28HCC19 ESRD21HCC46 ESRD24HCC46 RX08HCC16

Presence is a property of the code. Untick a model to hide it everywhere.

This code

Billable: yes
Code set: FY2026
Parent: D75.8
Block: D70-D77
Siblings: 4

Present FY2024–FY2027.