D57.459

Sickle-cell thalassemia beta plus with crisis, unspecified

Billable FY2026 2025-10-01 → 2026-09-30

This is the unspecified option. 5 more specific codes sit alongside it. Worth checking whether the documentation supports one of them.

Exclusions 10 never code together

D57code

Excludes1

other hemoglobinopathies (D58.-)D58.-

D50-D89chapter

Excludes2

autoimmune disease (systemic) NOS (M35.9)M35.9
certain conditions originating in the perinatal period (P00-P96)P00-P96
complications of pregnancy, childbirth and the puerperium (O00-O9A)O00-O9A
congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)Q00-Q99
endocrine, nutritional and metabolic diseases (E00-E88)E00-E88
human immunodeficiency virus [HIV] disease (B20)B20
injury, poisoning and certain other consequences of external causes (S00-T88)S00-T88
neoplasms (C00-D49)C00-D49
symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)R00-R94

Excludes1 — never code together. The excluded condition and this one are mutually exclusive.

Excludes2 — not included here, but the patient may have both. Code both when documented.

Instructional notes 7

D57.459code

Inclusion terms

HbS-beta plus with crisis with unspecified complication
Sickle-cell beta plus with crisis with unspecified complication
Sickle-cell thalassemia beta plus with (painful) crisis NOS
Sickle-cell thalassemia beta plus with (vaso-occlusive) pain NOS

D57.4code

Inclusion terms

Sickle-cell beta thalassemia
Thalassemia Hb-S disease

D57code

Use additional code

code for any associated fever (R50.81)R50.81

Index entries leading here 2

Arthropathy M12.9
- gouty — see also Gout
  - in (due to)
    - sickle-cell disorders D57
Disease, diseased — see also Syndrome
- hemoglobin or Hb
  - S or SS D57.1
    - beta plus D57.44
      - with
        
        crisis D57.459
        pain (vaso-occlusive) D57.459
- sickle-cell D57.1
  - thalassemia D57.40
    - beta plus D57.44
      - with
        
        crisis D57.459
        pain (vaso-occlusive) D57.459

Alongside this code 5 same parent — D57.45

D57.451 Sickle-cell thalassemia beta plus with acute chest syndrome D57.452 Sickle-cell thalassemia beta plus with splenic sequestration D57.453 Sickle-cell thalassemia beta plus with cereb vascular invl D57.454 Sickle-cell thalassemia beta plus with dactylitis D57.458 Sickle-cell thalassemia beta plus with crisis with oth comp

Medications 1

2 beta-Thalassemia drugs

MED-RT files conditions by MeSH, which carves the world differently from ICD-10. These are name matches on this code's description, offered as candidates — not as an assertion that they are this code.

Additional references

AHA Coding Clinic® Licence required

Official coding advice for this code. Published by the American Hospital Association. Not included in this installation.

Risk adjustment

CMS22HCC46 CMS28HCC108 ESRD21HCC46 ESRD24HCC46

Presence is a property of the code. Untick a model to hide it everywhere.

This code

Billable: yes
Code set: FY2026
Parent: D57.45
Block: D55-D59
Siblings: 5

Present FY2024–FY2027.