D57.45
Sickle-cell thalassemia beta plus with crisis
Not billable — category only FY2026 2025-10-01 → 2026-09-30
Exclusions 10 never code together
D50-D89chapter
Excludes2
- autoimmune disease (systemic) NOS (M35.9)M35.9
- certain conditions originating in the perinatal period (P00-P96)P00-P96
- complications of pregnancy, childbirth and the puerperium (O00-O9A)O00-O9A
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)Q00-Q99
- endocrine, nutritional and metabolic diseases (E00-E88)E00-E88
- human immunodeficiency virus [HIV] disease (B20)B20
- injury, poisoning and certain other consequences of external causes (S00-T88)S00-T88
- neoplasms (C00-D49)C00-D49
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)R00-R94
Excludes1 — never code together. The excluded condition and this one are mutually exclusive.
Excludes2 — not included here, but the patient may have both. Code both when documented.
Instructional notes 5
Index entries leading here 1
Alongside this code 5 same parent — D57.4
Subordinate codes 6
D57.451 Sickle-cell thalassemia beta plus with acute chest syndrome D57.452 Sickle-cell thalassemia beta plus with splenic sequestration D57.453 Sickle-cell thalassemia beta plus with cereb vascular invl D57.454 Sickle-cell thalassemia beta plus with dactylitis D57.458 Sickle-cell thalassemia beta plus with crisis with oth comp D57.459 Sickle-cell thalassemia beta plus with crisis, unspecified
Medications 1
MED-RT files conditions by MeSH, which carves the world differently from ICD-10. These are name matches on this code's description, offered as candidates — not as an assertion that they are this code.
Additional references
AHA Coding Clinic® Licence required
Official coding advice for this code. Published by the American Hospital Association. Not included in this installation.